Natural rubber based coatings with guanidinium-monomer

A current paper presents the synthesis and biological activity of a new antimicrobial material based on natural rubber derived building blocks and an organic antibacterial monomer, covalently bound to the polymer network.

Purple chopsticks against a dark background.
Biological tests with three strains of pathogenic bacteria proved the strong activity of the novel coatings. Source: Giovanni Cancemi – -

The investigation focused on the synthesis of an original acrylate monomer bearing an organic biologically active moiety (a guanidinium group) and in its co-polymerisation in presence of telechelic acrylate oligomers, prepared from polyisoprene. The cross-linked films obtained have been characterised by InfraRed Spectroscopy, contact angle, and thermal analyses.

Bioactive monomer resistant to long water immersions

It was shown that no-leaching of the bioactive monomer occurred and that the material resisted to long water immersions. Polyisoprene coatings prepared from pure acrylate oligoisoprenes also showed a weak antimicrobial activity that was drastically increased by integrating the guanidinium monomer. Biological tests carried out with three strains of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis) proved the strong activity of the coatings.

The study is published in: Progress in Organic Coatings Volume 128, March 2019, Pages 196-209.

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