The new compounds possessed high antibacterial activity and a minimal inhibitory concentration value. Source: Falkenpost / Pixabay.
17. Apr 2018 | Application Areas
Antifouling marine coatings of novel acylamino compounds
Scientists recently synthesised two novel antifoulant analogues of natural products including indole by Michael addition.
Basing on the previous syntheses of ester compounds containing gramine functional groups, the researchers synthesised two novel acylamino compounds containing gramine groups and the structures of target compound were established using 1HNMR, 13CNMR, IR spectra, and elemental analysis. The antibacterial activity of the synthesised compounds against Escherichia coli and Staphylococcus aureus, as well as their antifouling activity were studied.
Superior antifouling properties
The results showed that these compounds possessed high antibacterial activity and a minimal inhibitory concentration value of 0.03 mg/mL against bacteria. Moreover, their antifouling properties are superior to cuprous oxide and chlorothalonil, which are widely used as antifoulants. Furthermore, quantitative structure activity relationship studies with antibacterial activity of the nine gramine compounds were established. These provide theoretical and technical bases for preparing environment-friendly antifouling coatings with the compounds as antifouling agents.
The study is published in: Progress in Organic Coatings Volume 118, May 2018, Pages 141-147.
Image source: Pixabay
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