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13. May 2022 | Application Areas

ZnO nanoparticles against biofilm and bacteria

A new study has evaluated the in vitro efficacy of green synthesised ZnO nanoparticles against biofilm and virulence of Serratia marcescens.
The new study shows the efficacy of green fabricated ZnO NPs to inhibit the growth, biofilm, and virulence factor of S. marcescens. 
Image source: branislavp - (symbol image).

Zinc oxide reduced into nanosized exhibits antibacterial activity due to the interaction of ZnO with the cell surface and inside of the bacteria making them adaptive candidate for antibacterial activity. ZnO nanoparticles (ZnO NPs) synthesised using plant extract and their biomolecules makes them a safer, non-toxic and bactericidal solution against pathogenic bacteria. Till date, only few research articles are published on analysing the antibiofilm and anti-virulence activity of ZnO NPs synthesised using Ruellia tuberosa extract. A new study was now focused on synthesising ZnO NPs using Ruellia tuberosa and efficacy to inhibit biofilm formation and virulence factor of Serratia marcescens.

Efficacy of green fabricated ZnO NPs

ZnO NPs at the concentration of 100 μg/mL showed highest antibacterial activity by reducing S. marcescens growth upto 4-fold in comparison to untreated bacteria (1.8 OD600nm). ZnO NPs also showed 50% of inhibition of biofilm formation 25 μg/mL concentration. Microscopic analysis revealed the phenotypical change in the biofilm matrix formation after treating with >25 μg/mL of ZnO NPs. Prodigiosin, a quorum sensing regulated factor of S. marcescens was also inhibited >70% at 100 μg/mL concentration of ZnO NPs. Therefore, the present study shows the efficacy of green fabricated ZnO NPs to inhibit the growth, biofilm, and virulence factor of S. marcescens.

The study has been published in Progress in Organic Coatings, Volume 166, May 2022.

EC Techb Report Sustainability


EC Tech Report Sustainability

Making coating systems more environmentally compatible is a burning issue for everyone in the industry, and one that is being fuelled by the European Green Deal. Learn all you need to know about sustainable coatings, how to produce coatings in a more environmentally friendly way and how to give coated products a longer service life. You will find an overview in the EC Tech Report of the many various approaches being adopted. We will dive deep into the European Green Deal, its key points and main purpose as well as consequences for the coating industry, see which new raw materials are being developed to replace or lower the content of products in the SVHC group and learn about different approaches to sustainable paint formulation.

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