18. Mar 2021 | Application Areas
Novel injectable adhesive gel for wound healing
Skin tissue defects represent a major threat to human health. It is of vital importance for researchers to develop novel ideal adhesives with strong adhesion, good biocompatibility, low cost, and simple production approaches. Inspired by the phenomenon of free-radical scavenging by polyphenols, as well as the fact that polyphenols improve the mechanical properties of flour products, a tannic acid–thioctic acid (TATA) supramolecular hydrogel was synthesised via the ring-opening polymerisation of thioctic acid and thiyl radical–polyphenol Michael addition. As the researchers tell, the synthetic procedure was robust, facile, time-saving, and low-cost, and thus in accordance with the rules of green chemistry.
Adhesive for skin wound healing
Successful intermolecular crosslinking was confirmed using X-ray photoelectron spectroscopy (XPS). The multiple hydrogen bonds formed between the polyphenol residues and carboxyl groups endowed the hydrogel with self-healing and injectable properties. Additionally, the TATA hydrogel was used as an adhesive for skin wound healing, and it exhibited decreased therapeutic time and an enhanced regeneration effect compared with suture treatment. The hydrogel also showed antibacterial activity against Methicillin-resistant Staphylococcus aureus in a burn wound infection model.
Based on the above features, the TATA hydrogel exhibits potential as a surgical antibacterial bioadhesive for a broad range of medical applications.
The study has been published in Green Chemistry, Issue 4, 2021.
Microbicides in Coatings
All about biocides for coatings: When it comes to protecting coatings, it is essential to strike the right balance between controlling germs in order to avoid economic damage on the one hand and tolerating microbial life where it is necessary and useful on the other. The new book from Frank Sauer provides a comprehensive overview of the working mechanisms and possible applications of microbicides for coatings - invaluable for formulators and technicians as well as for business people with a basic knowledge of chemistry and biology.
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