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Wednesday, 26 February 2020
Raw materials & technologies, Technologies

Antibacterial properties of poly(dimethylsiloxane) surfaces

Thursday, 18 April 2019

In a recent study a graphene oxide-catechol hybrid poly(dimethylsiloxane) (PDMS-GO-DMA) surface was prepared. The surface exhibited antibacterial abilities in some degree.

The antibacterial ability of PDMS-GO-DMA surface was investigated. Image source: WikiImages / Pikxabay.

The antibacterial ability of PDMS-GO-DMA surface was investigated. Image source: WikiImages / Pikxabay.

Scientists have prepared the graphene oxide (GO)- a catechol derivative –dopamine methacrylamide monomer (DMA) composite modified poly (dimethylsiloxane) (PDMS) surfaces by π−π stacking of 1-pyrenebutyric acid on the GO and dopamine surface.

PDMS substrates were first oxidised by plasma to transform the Si−CH3 groups on their surfaces into Si−OH groups. Subsequently, aminopropyltriethoxysilane (γ-APS) was immobilised onto the PDMS−OH surface, and 1-pyrenebutyric acid (PA) was then bonded covalently onto the PDMS-γ-APS surfaces by the amidation reaction. Finally, PDMS-GO-DMA surfaces were prepared by modifying GO-DMA composites onto the PDMS-PA surface by π−π stacking between 1-pyrenebutyric acid and GO-DMA.

Various characterisation techniques were used

Various characterisation techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy (ATR-FTIR), and X-ray photoelectron spectroscopy (XPS), were used to ascertain the successful prepared the PDMS-GO-DMA surface.

The antibacterial ability of PDMS-GO-DMA surface was investigated by the classic colony and visible spectrophotometry methods. The results showed that PDMS-GO-DMA surface displayed antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria compared with native PDMS surface. Furthermore, the biocompatibility of the PDMS-GO-DMA has been studied by culturing the cell lines (HepG2 and A549) on the PDMS-GO-DMA surface which exhibited excellent biocompatibility.

Additionally, the results present possible uses for the PDMS–GO-DMA surface as antibacterial functional surfaces in biomedical microdevices applications.

The study has been published in: Progress in Organic Coatings, Volume 129, April 2019.

Image source: Pixabay.

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