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Home  > Raw materials & technologies  > Applications  > Protective & Marine coatings  > Loperamide-based compounds manage biofouling

Friday, 20 September 2019
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Raw materials & technologies, Applications, Protective & Marine coatings

Loperamide-based compounds manage biofouling

Monday, 24 February 2014

The commercial pharmaceutical "Imodium”, which contains the active ingredient loperamide hydrochloride, has been shown to have biofouling control properties.

Additives for marine applications help against biofouling

Source: Kaarsten/Fotolia

Additives for marine applications help against biofouling

Source: Kaarsten/Fotolia

However, due to concerns associated with safety and persistence of this active pharmaceutical ingredient (API) in the environment, the development of loperamide as an anti-fouling additive is not desirable. In a study, a team of Singaporean researchers from Agency for Science Technology and Research and Department of Pharmacy report their efforts directed towards the design and synthesis of small molecule antifoulants using the loperamide parent compound as the lead compound.

Compounds are useful as additives in marine coatings

These loperamide-based compounds can be synthesized readily and inexpensively. Several of the compounds identified are potentially useful as additives in marine antifouling coatings as they control attachment of barnacles in laboratory tests and an estimation program (BIOWIN) developed by the US Environmental Protection Agencypredicts that they will degrade completely in weeks to months.

The study is published in: International Biodeterioration & Biodegradation, Volume 89, April 2014, p. 82-87

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