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Sunday, 23 February 2020
Raw materials & technologies, Applications

Multifunctional coating improves the acceptance of implants

Friday, 23 October 2015

Major problems with biomedical devices in particular implants located in nonsterile environments concern: excessive immune response to the implant, development of bacterial biofilms and yeast and fungi infections.

Antibacterial and antifungal activities of the new system were successfully tested. Source: Aka/

Antibacterial and antifungal activities of the new system were successfully tested. Source: Aka/

An original multifunctional coating that addresses all these issues concomitantly is developed.

PAR film develops antimicrobial activity

A new exponentially growing polyelectrolyte multilayer film based on polyarginine (PAR) and hyaluronic acid (HA) is designed. The films have a strong inhibitory effect on the production of inflammatory cytokines released by human primary macrophage subpopulations. This could reduce potential chronic inflammatory reaction following implantation. Next, it is shown that PAR, due to its positive charges, has an antimicrobial activity in film format against Staphylococcus aureus for 24 h. In order to have a long-term antimicrobial activity, a precursor nanoscale silver coating is deposited on the surface before adding the PAR/HA films. Moreover, the PAR/HA films can be easily further functionalised by embedding antimicrobial peptides, like catestatin (CAT), a natural host defense peptide. This PAR/HA+CAT film proves to be effective as an antimicrobial coating against yeast and fungi and its cytocompatibility is also assessed. Finally, this all-in-one system constitutes an original strategy to limit inflammation and prevents bacteria, yeast, and fungi infections.

The study is published in: Advanced Healthcare Materials, Volume 4, Issue 13, pages 2026–2036, 16 September, 2015

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