Coding and decoding libraries of functional copolymers synthesised via photoligation
Monday, 5 December 2016
Designing artificial macromolecules with absolute sequence order represents a considerable challenge. Researchers report an advanced light-induced avenue to monodisperse functional linear macromolecules up to decamers via a new photochemical approach.
The versatility of the synthetic strategy - combining sequential and modular concepts - enables the synthesis of perfect macromolecules varying in chemical constitution and topology.
Viable and advanced concept
Specific functions are placed at arbitrary positions along the chain via the successive addition of monomer units and blocks, leading to a library of functional homopolymers, alternating copolymers and block copolymers. The in-depth characterisation of each sequence-defined chain confirms the precision nature of the macromolecules. Decoding of the functional information contained in the molecular structure is achieved via tandem mass spectrometry without recourse to their synthetic history, showing that the sequence information can be read. The scientists submit that the presented photochemical strategy is a viable and advanced concept for coding individual monomer units along a macromolecular chain.
The study is published in: Nature Communications 7, 2016.